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目的：研究７ 名健康志愿者单剂量口服茶碱控释胶囊（ 简称ＣＲＴＣ）４００ ｍｇ 后的药物动力学。方法：用紫外法测定健康人血清中茶碱的血药浓度。结果：ＣＲＴＣ的药物动力学参数分别为：Ｔｍａｘ ＝ （７ ．９ ±１．１）ｈ，Ｃｍａｘ ＝ （４．０ ±０ ．９）μｇ·ｍｌ－１ ，Ｔ１／２ｅ ＝（１７ ．２±２ ．６）ｈ，Ｋｅ ＝（０．０４±０．０６）ｈ－１ ，Ｔ１／２ａ＝ （２ ．１±０ ．９）ｈ，Ｋａ＝（０．２３±０．０４）ｈ－ １ ，ＡＵＣ０７２ ＝ （１３８ ．０±１７ ．６）μｇ·ｈ·ｍｌ－ １ 。结论：ＣＲＴＣ的药物动力学参数与国产茶碱控释片（ 简称ＤＣＲＴＴ）［１］ 相比：其吸收减慢，导致达峰时间延长，达峰浓度降低。但其消除减慢，ＣＲＴＣ在体内蓄积，致使其药时曲线下的面积较ＤＣＲＴＴ 大。
OBJECTIVE: To study the pharmacokinetics of 400 mg single-dose oral theophylline controlled-release capsules (CRTC) in seven healthy volunteers. Methods: The plasma concentration of theophylline in healthy human serum was determined by UV method. Results: The pharmacokinetic parameters of CRTC were: Tmax = (7.9 ± 1.1) h, Cmax = (4.0 ± 0.9) μg · ml-1, T1 / 2e = Ke = (0.04 ± 0.06) h-1, T1 / 2a = (2.1 ± 0.9) h, Ka = 0.23 ± 0.04 h-1 , AUC0 72 = (138.0 ± 17.6) μg · h · ml-1. CONCLUSION: The pharmacokinetic parameters of CRTC are lower than those of domestic controlled-release tablets of theophylline (DCRTT) [1], leading to prolonged peak time and decreased peak concentration. However, its elimination slowed down and the accumulation of CRTC in the body resulted in a larger area under the drug curve than that of DCRTT.