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目的探讨糖尿病人群基线腰围水平与新发高血压风险之间的关系。方法本研究采用前瞻性队列研究方法,以参加2006-2007年度开滦集团职工健康体检,收缩压<140mm Hg且舒张压<90mm Hg及既往无高血压病史,相关资料完整的2468例糖尿病人群作为观察队列。依据基线腰围四分位数将观察对象分为4组(第一分位组:腰围<84cm;第二分位组:腰围84~<89cm;第三分位组:腰围89~<95cm;第四分位组:腰围≥95cm),比较4组2010-2011年度健康体检时高血压的发病率,并用Cox比例风险回归模型分析基线腰围与新发高血压风险的关系。结果观察队列的平均随访时间为(47.2±5.1)月,有976例发生了高血压,发病率为39.5%。随着腰围的增加,高血压的发病率逐渐升高,腰围第一分位、第二分位、第三分位和第四分位组的发病率分别为30.3%、37.4%、42.2%和47.6%(趋势P值<0.01)。影响新发高血压的Cox比例风险回归模型分析显示,腰围是新发高血压的独立危险因素,与第一分位组比较,第三分位组和第四分位组新发高血压的风险分别增加26.2%和46.8%。结论腰围≥89cm是糖尿病人群新发高血压的独立危险因素。
Objective To investigate the relationship between baseline waist circumference and the risk of new-onset hypertension in diabetic population. Methods A prospective cohort study was conducted in a prospective cohort study to evaluate the health status of workers in Kailuan Group from 2006 to 2007 with systolic blood pressure <140 mm Hg and diastolic blood pressure <90 mm Hg and 2468 diabetics with no previous history of hypertension. Watch the queue. According to the baseline waist circumference quartiles, the subjects were divided into four groups (the first interquartile range: <84cm in the waist; the second interquartile range: 84 ~ <89cm in the waist; the third in the range: 89 ~ <95cm in the waist; Quartile: waist circumference ≥95cm). The incidence of hypertension during the physical examinations was compared between the four groups in 2010-2011. The relationship between baseline waist circumference and new-onset hypertension was analyzed by Cox proportional hazards regression model. Results The average follow-up time of the observation cohort was (47.2 ± 5.1) months, with 976 cases of high blood pressure, with an incidence of 39.5%. With the increase of waist circumference, the incidence of hypertension increased gradually. The incidence rates of the first, second, third and fourth interquartile range of the waist circumference were 30.3%, 37.4%, 42.2% and 47.6% (trend P value <0.01). Cox proportional hazards regression analysis showed that waist circumference was an independent risk factor for new-onset hypertension. Compared with the first quintile, the risk of new hypertension in the third and fourth quintiles Increased by 26.2% and 46.8% respectively. Conclusion waist circumference ≥89cm is an independent risk factor for new-onset hypertension in diabetic population.