中性粒细胞（ＰＭＮ）是机体防御系统的主要组成部分。多种细胞因子能调节ＰＭＮ的凋亡，如ＴＮＦ－α能加速ＰＭＮ的凋亡；ＧＭ－ＣＳＦ，ＩＬ－２，ＩＬ－６和ＩＦＮ－γ等能延缓其凋亡，这些因子对ＰＭＮ凋亡的影响是通过不同机理而实现的。ＰＭＮ以凋亡的方式被机体清除，对于控制炎症组织的损伤和正常情况下炎症的消退都有很重要的意义 Neutrophils (PMNs) are a major part of the body’s defense system. A variety of cytokines can regulate PMN apoptosis, such as TNF-α can accelerate the apoptosis of PMN; GM-CSF, IL-2, IL-6 and IFN-γ can delay its apoptosis, these factors on PMN apoptosis The impact is achieved through different mechanisms. PMN is cleared by the body in the manner of apoptosis, which is very important for controlling the damage of inflammatory tissues and the subsidence of inflammation under normal conditions