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目的 探讨口腔粘膜下纤维变性（ＯＳＦ） 中胶原堆积的原因。方法 电镜下对ＯＳＦ 患者病变部位中胶原纤维进行研究，测量胶原原纤维的直径及周期性横纹。结果 ①胶原原纤维的直径：ＯＳＦ早期原纤维直径与正常无差别，中期、晚期直径逐渐增大；②周期性横纹：ＯＳＦ早期与正常无差别，中期、晚期逐渐增大。结论 ＯＳＦ 的胶原纤维的形态表现异常，其程度随病变发展而加重。
Objective To investigate the causes of collagen accumulation in oral submucous fibrosis (OSF). Methods The collagen fibers in diseased part of OSF were studied under electron microscope, and the diameter and periodic striation of collagen fibrils were measured. Results ① The diameter of collagen fibrils: There was no difference in the diameter of the early fibrils of OSF and the diameter of the middle and late stages of OSF was gradually increased. ② The periodic striae: OSF was no difference in early and normal, and gradually increased in the middle and late stages. Conclusion The morphology of collagen fibers in OSF is abnormal and the degree of OSF aggravates with the development of the lesions.