论文部分内容阅读
胰多肽(Pancreatic Polypeptide,简称pp)是胰腺pp细胞分泌的一种消化道激素,其生物学作用包括:调节胰腺胰液的分泌,抑制胆汁分泌及胆囊收缩,增加胆总管括约肌的紧张性等。在一些吸收不良胃肠道手术后糖尿病、肾功能不全等患者中,pp血浆含量均有变化。本支就近年来有关pp的基础和临床研究作一简要概述。一、结构与命名 1968年Kimmel等先在鸟类中发现了这种激素(pp),且证实它们是由36个氨基酸直链多肽组成。牛、羊、猪和人的胰多肽在36个氨基酸中,只有1～2个氨基酸不同,但它们在36位羧基残端上均有酪氨酰胺,这个残端的生理作用非常重要。如除去这一残端即无抑制腺胰分泌的作用;如留其肽基端的6羧,即可保持其生物活性。该肽与结肠、回肠粘膜分泌的PYY,中枢神经系统特殊神
Pancreatic Polypeptide (PP) is a kind of gastrointestinal hormone secreted by pancreatic pp cells. Its biological functions include regulating the secretion of pancreatic juice, inhibiting bile secretion and gallbladder contraction, and increasing the tension of the common bile duct sphincter. In some cases of malabsorption of gastrointestinal tract surgery after diabetes, renal insufficiency and other patients, pp plasma levels have changed. This branch in recent years on pp basic and clinical research for a brief overview. First, the structure and nomenclature In 1968 Kimmel, etc. first found in birds of this hormone (pp), and confirmed that they are composed of 36 amino acid linear polypeptide. Cattle, sheep, pigs and human pancreatic polypeptide in 36 amino acids, only 1 to 2 amino acids are different, but they are in the 36 carboxyl residues are tyrosine amide, the physiological role of this stump is very important. Such as the removal of this stump that does not inhibit the secretion of the role of the gland and pancreas; such as leaving the carboxy-6 carboxyl end, you can maintain its biological activity. The peptide and the colon, ileal mucosa secreted PYY, a special god of the central nervous system