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胰多肽瘤是消化道内分泌肿瘤之一;其特征是分泌大量胰多肽,从而产生胰多肽所致之病理表现。 理论上,任何一种胃肠激素都有可能产生其相应的内分泌激素肿瘤;但实际上,目前病例较多且足以称为一独立疾病的只有胰岛素瘤、胃泌素瘤、血管活性肠肽瘤、生长抑素瘤、胰高糖素瘤和类癌等。其他偶见病例有分泌胆囊收缩素、肠抑胃肽、肠高糖素,ACTH、降钙素、神经降压素、胰生长激素释放因子等肿瘤,此外,尚有胰岛细胞弥漫增生所产生之胰岛素增多症等。 文献上胃肠道内分泌瘤的共同特征是肿瘤较小,临床表现为相应激素大量分泌所引起的病理生理表现,基本无肿瘤侵袭、压迫表现。而胰多肽瘤,则有不少病例同时呈肿瘤侵袭压迫现象。文献上尚未见到综合许多病例系统描述的胰多肽瘤。兹将公开发表的16例资料编纂而成本文。
Pancreatic polypeptide tumors are one of the endocrine tumors of the digestive tract; they are characterized by the secretion of a large number of pancreatic polypeptides, resulting in the pathological manifestation of pancreatic polypeptide. In theory, any kind of gastro-intestinal hormone may produce its corresponding endocrine hormone tumor; but in fact, there are more cases and enough to be called an independent disease only insulinoma, gastrinoma, vasoactive intestinal peptide tumor , somatostatin tumors, glucagon tumors, and carcinoids. Other occasional cases have secreted cholecystokinin, enteroinhibitory peptide, glucagon, ACTH, calcitonin, neurotensin, pancreatic growth hormone releasing factor and other tumors, in addition, there are still diffuse proliferation of islet cells Insulinosis and so on. The common feature of the gastrointestinal endocrine tumors in the literature is that the tumors are small, and the clinical manifestations are the pathophysiological manifestations caused by the secretion of corresponding hormones, and there is basically no tumor invasion and oppression performance. The pancreatic polypeptide tumor, there are many cases at the same time showed tumor invasion and oppression. No pancreatic polypeptide tumor has been described in many cases systematically in the literature. 16 publicly-published materials are compiled into this paper.