用放射免疫法测定肝硬化病人的血清Ⅲ型前胶原（ＰＣⅢ）及Ⅳ型胶原（Ⅳ－Ｃ）并与正常对照作比较，以探讨ＰＣⅢ、Ⅳ－Ｃ与肝硬化的关系。测定的１０９例中，正常对照３８例、肝硬化７１例。结果显示：肝硬化病人血清ＰＣⅢ、Ⅳ－Ｃ的含量分别为１８０１３±７００７μｇ／Ｌ及１６２５１±４４１５μｇ／Ｌ，明显高于对照组的８８００±２１０３μｇ／Ｌ和９７８８±１６７２μｇ／Ｌ，ｐ值均小于００１。ＰＣⅢ的异常率为９３７５％，Ⅳ－Ｃ的异常率为９２３１％，按ｃｈｉｌｄｐｕｇｈ分级法，肝硬化病人血清ＰＣⅢ、Ⅳ－Ｃ的含量随分级程度的加重其含量也逐步增高，而血清ＰＣⅢ、Ⅳ－Ｃ的含量与转氨酶、白蛋白、胆红素含量间无明显相关，提示血清ＰＣⅢ、Ⅳ－Ｃ二者对评估肝硬化肝脏的代偿功能是很有价值的 Radioimmunoassay was used to determine the serum levels of type Ⅲ procollagen (Ⅲ) and type Ⅳ collagen (Ⅳ-C) in cirrhotic patients. The levels of PCⅢ, Ⅳ-C and cirrhosis were compared with those of normal controls. Among the 109 cases measured, 38 cases were normal control and 71 cases were cirrhosis. The results showed that the serum levels of PCⅢ and Ⅳ-C in patients with cirrhosis were 18013 ± 7007μg / L and 16251 ± 4415μg / L, respectively, which were significantly higher than those in the control group (8800 ± 2103μg / L and 9788 ± 1672 μg / L, respectively, the p values ​​were less than 001. The abnormal rate of PC Ⅲ was 9375% and the abnormal rate of Ⅳ-C was 9231%. According to the method of childpugh, the content of PCⅢ and Ⅳ-C in patients with cirrhosis increased gradually with the degree of grading , While there was no significant correlation between the levels of PCⅢ and Ⅳ-C in serum and aminotransferase, albumin and bilirubin, which suggested that both PCⅢ and Ⅳ-C were valuable in assessing liver compensatory function of liver cirrhosis