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目的 :探讨患者血清PCⅢ及Ⅳ -C升高在肝硬化及原发性肝癌诊断中的意义。方法 :用免疫放射的方法检测 76例肝硬化及 4 3例原发性肝癌患者血清的PCⅢ及Ⅳ -C。结果 :肝硬化组血清PCⅢ 12 6 0 9(± 4 6 36 ) μg/L ;Ⅳ -C6 1 0 9(± 2 8 50 ) μg/L。与对照组相比P <0 0 0 1。单纯型原发性肝癌PCⅢ 12 8 6 7(± 38 2 5) μg/L ;Ⅳ -C6 9 4 7(± 2 4 6 1) μg/L ,与对照组相比P <0 0 0 1。硬化型原发性肝癌PCⅢ 146 4 (± 4 5 88) μg/L ;Ⅳ -C10 7 50 (± 73 39)与对照组相比P <0 .0 0 1。结论 :肝硬化及原发性肝癌PCⅢ、Ⅳ -C在患者血清中升高。这两个指标分别与AFP联用诊断原发必肝癌 ,其敏感性优于单用AFP ,但特异性较差。
Objective: To investigate the significance of elevated serum PCⅢ and Ⅳ-C levels in the diagnosis of cirrhosis and primary liver cancer. Methods: Serum samples of PCⅢ and Ⅳ-C from 76 patients with liver cirrhosis and 43 patients with primary liver cancer were detected by immuno-radioactive method. Results: The serum levels of PCⅢ in patients with cirrhosis were 12 6 0 9 (± 4 6 36) μg / L and Ⅳ -C 6 1 0 9 (± 2 8 50) μg / L. P <0 0 0 1 compared with the control group. PC Ⅲ 12 867 (± 38 2 5) μg / L and Ⅳ-C 6 947 (± 2 4 6 1) μg / L were significantly higher than those in the control group (P <0.01). PC Ⅲ 146 4 (± 4 5 88) μg / L in cirrhotic primary hepatocellular carcinoma; Ⅳ-C10 7 50 (± 73 39) P <0.001 compared with the control group. Conclusion: PCⅢ and Ⅳ-C in cirrhosis and primary liver cancer are elevated in the serum of patients. The two indicators were associated with AFP diagnosis of primary liver cancer, its sensitivity is better than single AFP, but the specificity is poor.