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目的:观察祛瘀消痛贴膏联合美施康定对恶性肿瘤伴癌性疼痛患者的疼痛缓解效果及生活质量的影响。方法:75例癌症患者随机分为观察组与对照组。观察组予祛瘀消痛贴膏联合美施康定治疗,对照组仅给予美施康定。以疼痛数字评价量表(NRS)评分和生活质量(QOL)评分法于治疗前后评价患者的疼痛程度和生活质量,并记录治疗后药物起效时间及持续镇痛时间。定期随访,记录不良反应。结果:观察组持续镇痛时间和起效时间均优于对照组(P<0.05),NRS评分显著低于对照组(P<0.05);两组患者治疗前QOL评分差异无统计学意义,治疗后观察组QOL评分明显高于对照组(P<0.05);观察组临床症状总改善率高于对照组(P<0.05),不良反应发生率低于对照组(P<0.05)。结论:祛瘀消痛贴膏联合美施康定可缓解恶性肿瘤患者的癌性疼痛,患者不良反应小,并有助于提高患者生活质量。
Objective: To observe the effect of Quyu Xiaozong plaster combined with Mischitidine on pain relief and quality of life in patients with malignant tumor and cancer pain. Methods: Seventy-five cancer patients were randomly divided into observation group and control group. The observation group was treated with Stasis and Gutting plaster combined with Meishen Kangding, while the control group only given Meishen Kangding. Patients’ pain and quality of life were evaluated before and after treatment by the NRS score and QOL score, and the time of onset of medication and duration of analgesia after treatment were recorded. Regular follow-up, record adverse reactions. Results: The duration of analgesia and the onset time of the observation group were better than those of the control group (P <0.05), and the NRS scores were significantly lower than those of the control group (P <0.05). There was no significant difference in the QOL scores between the two groups before treatment The postoperative QOL score in the observation group was significantly higher than that in the control group (P <0.05). The overall clinical symptom improvement rate in the observation group was higher than that in the control group (P <0.05), and the incidence of adverse reactions was lower than that in the control group (P <0.05). Conclusion: Stasis and Relieving Gutting plaster combined with Mischitidine can relieve the cancerous pain in patients with malignant tumors, with less adverse reactions and help to improve the quality of life of patients.