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自三烯类是一类花生四烯酸(AA)的5-脂氧合酶(5-lo)代谢通路的产物,具有多种生物学活性,与炎性疾病、肿瘤和老年性痴呆等有密切的关系。5-lo是这一通路的关键酶,可催化AA转变为5-氢过氧化二十碳四烯酸(5-HPETE),并进一步使其转化为白三烯A4(LTA4)。5-lo的活性除了依赖钙离子和ATP外,还必须有5-脂氧合酶激活蛋白(FLAP)的存在。5-lo和5-脂氧合酶激活蛋白(flap)都不是看家基因。5-lo和flap表达于中性粒细胞、单核巨噬细胞和肥大细胞等细胞中。人外周血单核细胞在培养到第6 d后,表现
Triene is a product of 5-lipoxygenase (5-lo) metabolic pathway of arachidonic acid (AA), has a variety of biological activity, and inflammatory diseases, cancer and senile dementia have close relationship. 5-lo, a key enzyme in this pathway, catalyzes the conversion of AA to 5-HPETE and further converts it to leukotriene A4 (LTA4). The 5-lo activity requires the presence of 5-lipoxygenase activating protein (FLAP) in addition to calcium and ATP. Neither 5-lo nor 5-lipoxygenase activators are housekeeping genes. 5-lo and flap expression in neutrophils, monocytes and mast cells and other cells. Human peripheral blood mononuclear cells in the training to the first 6 d, the performance