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本文试图证明鼻滴不同剂量的促黄体素释放激素(LRH)的高活性类似物对正常妇女排卵的影响。作者在39例月经规律的健康妇女,每天鼻内应用1次LRH的高活性类似物(D-ser(TBU)~6-E-A~(10)-LRH)。自月经的头3天内开始用药,持续用26～35天或更长。根据每天用药的剂量分为3组:1组,87微克或174微克;2组,348微克;3组,400微克或600微克。用药期间做临床检查,记录基础体温图并反复取静脉血测定血清卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇及孕酮水平。结果表明,不同剂量的该类似物抑制排卵的效力也异。1组8例用药期间均显示卵泡生长,血清
This article attempts to demonstrate the effect of nasal drops of different doses of high activity analogs of luteinizing hormone releasing hormone (LRH) on ovulation in normal women. In 39 healthy women with regular menstrual flow, high-activity LRH analogues (D-ser (TBU) ~ 6-E-A ~ (10) -LRH) were administered intranasally once a day. Medication should be started within the first 3 days of menstruation for 26-35 days or longer. Divided into 3 groups according to the daily dosage: group 1, 87 microgram or 174 microgram; group 2, 348 microgram; group 3, 400 microgram or 600 microgram. During the period of medication, the patients were given clinical examination, basal body temperature chart was recorded, and venous blood samples were taken to determine serum FSH, LH, estradiol and progesterone levels. The results show that different doses of the analogs inhibit ovulation efficiency also vary. A group of 8 patients during the treatment showed follicular growth, serum