动物实验和健康人体药动学研究证明,甲氰咪胍是一种强效肝药酶抑制剂,其通过抑制药物肝内代谢Ⅰ级过程和减少肝血流量二种方式,影响多种药物的体内消除。甲氰咪胍对某些治疗指数狭窄、药理效应显著的药物的肝内代谢的抑制,易产生明显的不良反应。 Animal experiments and healthy human pharmacokinetic studies have shown that cimetidine is a potent hepatic drug inhibitor, which through the inhibition of drug liver level Ⅰ metabolism process and reduce blood flow in two ways, affecting a variety of drugs In vivo elimination. Cimetidine for some therapeutic index is narrow, significant pharmacological effects of intrahepatic metabolism of drugs, easy to produce significant adverse reactions.