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近年来严重的支气管哮喘病人增多,对多种致敏原(包括某些药物)过敏,综合治疗中不得不使用糖皮质激素,长期使用即出现固醇类依赖型支气管哮喘,有些病例虽经积极治疗仍然死亡。据文献报道,死亡的主要原因是肾上腺皮质萎缩、氧血低性昏迷和播散性血管内凝血。作者分析11例重型固醇类依赖型支气管哮喘病人的死亡原因,年龄20～60岁10例,60岁以上1例。疾病迁延时间2～18年。有7例入院时主诉呼吸困难,全身衰弱很明显,已连续使用糖皮质激素1.5～15年(每日强的松龙10～15mg)。其中有4例与近来哮喘加重和随意停用激素或减少激素用量有关。入院时病情很严重,诊断为感染性变应性支气管哮喘Ⅱ～Ⅲ期,固醇
In recent years, serious patients with bronchial asthma increased, allergic to a variety of allergens (including some drugs) allergies, had to use glucocorticoid in the comprehensive treatment, long-term use of steroid-dependent bronchial asthma, although some cases have been positive Treatment is still dead. According to the literature, the main cause of death is adrenal cortex atrophy, low blood oxygen coma and disseminated intravascular coagulation. The authors analyzed the causes of death in 11 patients with steroid-dependent bronchial asthma, 10 patients aged 20 to 60 years and 1 patient aged 60 years and older. Disease delay of 2 to 18 years. There are 7 cases of admission complained of dyspnea, systemic weakness is obvious, continuous use of glucocorticoid 1.5 to 15 years (daily prednisolone 10 ~ 15mg). Of these, 4 were associated with more recent asthma exacerbations and random steroid use or reduced hormone dosage. Serious illness on admission, diagnosis of infectious allergic bronchial asthma Ⅱ ~ Ⅲ, sterol