论文部分内容阅读
目的:观察羟基脲、替加氟及亚叶酸钙联合方案治疗经一线标准方案化疗后失败或进展的晚期鼻咽癌近期疗效以及有效病例中位维持有效时间。方法:27例均经5-FU+CF+DDP一线标准方案化疗后失败或进展的晚期鼻咽癌患者予口服化疗:羟基脲0.5 g,Bid,d1～14;替加氟300 mg,Tid,d1～30;亚叶酸钙15 mg,Tid,d1～30;一个月为一个疗程。直到病情进展为止。结果:羟基脲、替加氟及亚叶酸钙联合方案治疗有效率为40.74%,有效病例中位缓解期为7个月。不良反应主要是骨髓抑制、恶心、食欲下降等,均在I度范围内。结论:羟基脲、替加氟及亚叶酸钙联合方案治疗经一线标准方案化疗后失败或进展的晚期鼻咽癌有一定的治疗价值,对有效者能明显延长疾病进展时间,更为优越的是不良反应轻微,安全性高,治疗费用低廉,给药途径简单方便,医从性好,可以用于门诊治疗,值得进一步临床观察应用。
OBJECTIVE: To observe the short-term efficacy of hydroxyurea, tegafur and leucovorin combination regimen in the treatment of advanced nasopharyngeal carcinoma who failed or progress after first-line standard chemotherapy and the median effective maintenance time. Methods: Twenty-seven patients with advanced nasopharyngeal carcinoma who failed or progressed after 5-FU + CF + DDP first-line chemotherapy were given orally with hydroxyurea 0.5 g, Bid, d1-14, tegafur 300 mg, Tid, d1 ~ 30; leucovorin 15 mg, Tid, d1 ~ 30; one month for a course of treatment. Until the disease progresses. Results: The effective rate of hydroxyurea, tegafur and leucovorin combination regimen was 40.74%, and the median effective remission period was 7 months. Adverse reactions are mainly bone marrow suppression, nausea, loss of appetite, etc., are in the I degree range. CONCLUSION: Hydroxyurea, tegafur and leucovorin combination regimen have some therapeutic value in the treatment of advanced nasopharyngeal carcinoma after failing or progressing by first-line standard chemotherapy, and the effective time can significantly prolong the time of disease progression. More superior Minor adverse reactions, high safety, low cost of treatment, simple and convenient route of administration, good medicine, can be used for outpatient treatment, it is worth further clinical observation and application.