吡嗪酰胺(PZA)引起口腔溃疡和全身性皮炎,我院先后收治过2例,现将典型的1例报告如下。病例报告患者女,20岁,住院号51600。因咳嗽、血丝痰1周到某医院诊治。X线胸片示双肺有斑片状阴影、右上肺有空洞,痰涂片发现抗酸杆菌,诊断为“肺结核”。当地医院给予肌注“链霉素”和口服“异烟肼、利福平、吡嗪酰胺”等药治疗。用药2周后出现咽喉疼痛,张口困难,进食和讲话困难,随后出现全身皮肤潮红伴有暗红色皮疹,停用上述抗结核药。在当地医治未见好转,于1993年3月13日转来我院住 Pyrazinamide (PZA) cause mouth ulcers and systemic dermatitis, our hospital has admitted to 2 cases, now a typical case reported as follows. Case report Female patient, 20 years old, hospital number 51600. Due to cough, bloody sputum 1 week to a hospital for treatment. X-ray chest lungs showed patchy shadows, there is a hole in the right upper lung, sputum smear found acid-fast bacilli, diagnosed as “tuberculosis.” Local hospital for intramuscular “streptomycin” and oral “isoniazid, rifampicin, pyrazinamide” and other drug treatment. After 2 weeks of medication, sore throat, mouth opening difficulties, difficulty in eating and speaking, followed by systemic flushing with dark red skin rash, disable the anti-TB drugs. In the local medical treatment did not improve, in March 13, 1993 transferred to our hospital