临床实践中,吡喹酮对患者神经系统的付反应主要有:乏力、头晕、头痛、失眠、多梦、暂时性记忆力减退等,极少数颇似精神分裂症。现将我县1990-1992年间吡喹酮对患者产生精神障碍的两个病例报告如下: 例1,女,32岁,务农。平素身体健康。其家族与本人无精神病史,无血吸虫病治疗史,但有疫水接触史。患者因乏力、纳差、食后上腹饱胀及间断腹泻,身体逐日消瘦,故来我院就诊。经血吸虫免疫学检查结果为阳性(间接血凝1∶10;环卵沉淀试验率6%)。在我院予以吡喹酮60mg/kg分二日治疗。治疗前检查心、肺无异常,肝功能、心电图均正 Clinical practice, praziquantel on the patient’s nervous system pay the main reaction are: fatigue, dizziness, headache, insomnia, dreams, temporary memory loss, a very small number of similar to schizophrenia. Now my county 1990-1992 praziquantel patients with mental disorders in two cases are reported as follows: Example 1, female, 32 years old, farming. Normal physical health. The family and I have no history of mental illness, no history of treatment of schistosomiasis, but there is a history of exposure to water. Patients due to fatigue, anorexia, abdominal fullness after eating and intermittent diarrhea, the body weight loss day by day, it came to our hospital. Schistosoma immunization test results were positive (indirect hemagglutination 1:10; ring egg precipitation test rate of 6%). In our hospital to praziquantel 60mg / kg sub-day treatment. Before treatment check heart, lung no abnormalities, liver function, ECG are positive