The eastern Xing’an-Mongolian (Xing-Meng) Orogenic Belt (XMOB) is one of the important areas of porphyry copper (Cu)-molybdenum (Mo) deposits in China. However, studies on the exact ages of mineralization and their geodynamic significance are very limited. In this study, granodioritic rocks from the Duobaoshan Cu deposit and Daheishan Mo deposit were selected to make zircon SHRIMP U-Pb analyses in order to constrain their mineralization ages. Geochronological data indicate that two episodes of mineralization took place in the Duobaoshan Cu deposits. The granodiorite related to the Duobaoshan porphyry Cu deposit was formed in the Early Paleozoic with zircon U-Pb age of 485±8 Ma, whereas the granodiorites related to the Sankuanggou skarn-type Cu deposit were emplaced in the Jurassic with zircon U-Pb ages of 176±3 and 177±3 Ma. In the Daheishan area of Jilin Province, the emplacement age of the granodiorite porphyry related to the porphyry Mo deposit was dated at 170±3 Ma, and the unmineralized monzogranite at 178±3 Ma. Therefore, two episodes of Cu-Mo mineralization were developed in the eastern XMOB, at ~485 Ma and ~175 Ma, respectively. Based on the geological history and spatial-temporal distribution of the granitoids in northeastern (NE) China, it is proposed that the Duobaoshan Cu deposit was related to the collision of the Xing’an and Erguna blocks in the Early Paleozoic, and the Sankuanggou Cu and Daheishan Mo deposits were related to subduction of the Paleo-Pacific plate during the Jurassic. The eastern Xing’an-Mongolian (Xing-Meng) Orogenic Belt (XMOB) is one of the important areas of porphyry copper (Cu) -molybdenum (Mo) deposits in China. However, studies on the exact ages of mineralization and their geodynamic Significance this very limited. In this study, granodioritic rocks from the Duobaoshan Cu deposit and Daheishan Mo deposit were selected to make zircon SHRIMP U-Pb analyzes in order to constrain their mineralization ages. Geochronological data indicate that two episodes of mineralization took place in the Duobaoshan Cu deposits. The granodiorite related to the Duobaoshan porphyry Cu deposit was formed in the Early Paleozoic with zircon U-Pb age of 485 ± 8 Ma, whereas the granodiorites related to the Sankuanggou skarn-type Cu deposit were emplaced in the Jurassic with zircon U-Pb ages of 176 ± 3 and 177 ± 3 Ma. In the Daheishan area of ​​Jilin Province, the emplacement age of the granodiorite porphyry related to the porphyry Mo deposit was dated at 170 ± 3 Ma, and the u nmineralized monzogranite at 178 ± 3 Ma. Thus, two episodes of Cu-Mo mineralization were developed in the eastern XMOB, at ~ 485 Ma and ~ 175 Ma, respectively. Based on the geological history and spatial-temporal distribution of the granitoids in northeastern (NE) China, it is proposed that the Duobaoshan Cu deposit was related to the collision of the Xing’an and Erguna blocks in the Early Paleozoic, and the Sankuanggou Cu and Daheishan Mo deposits were related to subduction of the Paleo-Pacific plate during the Jurassic.