局部应用皮质激素引起皮质醇增多症者很少见,本文报告3例在局部应用一种强效的皮质激素新制剂氯氟美松(Clobetasol Propionate)后,发生类皮质醇增多症的临床表现。检查了这3例病人和另1例病人(都患牛皮癣)的垂体与肾上腺的机能。发现他们在用本药后,血清中氢化可的松水平持久地显著降低,均低于1微克/100毫升。停药后有3例发生肾上 Topical application of corticosteroids cause cortisol hyperactivity disorder are rare, the paper reported 3 cases of local application of a potent new hormone corticosteroid formulations of Clobetasol Propionate, the clinical manifestations of corticosteroid. The pituitary and adrenal function was examined in these three patients and in another patient (both suffering from psoriasis). Found that they are using the drug, the serum levels of cortisol long-term significant reduction, are less than 1 microgram / 100 ml. After stopping the drug in 3 cases occurred on the kidney