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G蛋白耦联雌激素受体-1(G protein-coupled estrogen receptor 1,GPER-1)是一种新型的雌激素受体,能够介导雌激素的快速非基因组效应。GPER-1与雌激素具有高亲和力,能与天然雌激素和人工合成雌激素结合,快速激活细胞内第二信使或级联信号通路,间接调节转录活动,从而介导雌激素的生物学效应。GPER-1的亚细胞定位存在争议,因其亚细胞定位可能取决于不同的细胞类型。另外,性别、年龄等内在因素以及细胞外刺激、损伤等外在因素也影响GPER-1在质膜的相对丰度。近年来研究表明GPER-1的表达与女性生殖系统肿瘤的发生、发展密切相关,在卵巢癌组织中高表达,参与卵巢癌的发生发展,并可能作为评价卵巢癌患者预后的指标,有望成为卵巢癌重要的治疗靶点。
G protein-coupled estrogen receptor 1 (GPER-1) is a novel estrogen receptor that mediates the rapid non-genomic effects of estrogen. GPER-1 has high affinity with estrogen and can bind estrogen with natural estrogen and synthetic estrogen. GPER-1 can rapidly activate intracellular second messenger or cascade signaling pathway and indirectly regulate transcriptional activity to mediate estrogen biological effects. Subcellular localization of GPER-1 is controversial because its subcellular localization may depend on different cell types. In addition, gender, age and other internal factors and extracellular stimuli, damage and other external factors also affect the relative abundance of GPER-1 in the plasma membrane. In recent years, studies have shown that GPER-1 expression is closely related to the occurrence and development of female reproductive system tumors, highly expressed in ovarian cancer tissues, involved in the occurrence and development of ovarian cancer, and may be used as an indicator to evaluate the prognosis of ovarian cancer patients, is expected to become ovarian cancer Important therapeutic target.