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目的探讨入院慢性阻塞性肺疾病(COPD)并念珠菌性口炎患者的病原学特征以及相关危险因素。方法采用病例研究,对2007年4月1日至2011年1月31日入院的82例COPD并念珠菌性口炎患者和82例无念珠菌性口炎COPD患者进行匹配,应用SPSS 17.0统计软件行条件logistic回归模型分析COPD患者念珠菌性口炎发生的危险因素。结果 (1)从念珠菌性口炎患者假膜培养共分离出念珠菌83株,以白念珠菌(90.4%)为最多,其次为光滑念珠菌(3.6%)、克柔念珠菌(2.4%)、热带念珠菌(2.4%)、近平滑念珠菌(1.2%);(2)统计学分析结果显示全身应用、吸入糖皮质激素是入院患者口腔念珠菌感染的独立危险因素。结论白色念珠菌是COPD患者口腔部念珠菌感染的主要病原菌,规范使用全身糖皮质激素、正确吸入糖皮质激素是预防COPD患者口腔念珠菌感染的关键。
Objective To investigate the etiological characteristics and related risk factors of patients with chronic obstructive pulmonary disease (COPD) and candidal stomatitis. Methods A case study was conducted to compare 82 COPD patients admitted with candidal stomatitis between January 1, 2007 and January 31, 2011 and 82 patients without Candida stomatitis. SPSS 17.0 software Conditioned logistic regression model was used to analyze the risk factors of Candida stomatitis in COPD patients. Candida albicans (90.4%) were the most common, followed by Candida glabrata (3.6%), Candida krusei (2.4%), Candida krusei ), Candida tropicalis (2.4%) and Candida parapsilosis (1.2%). (2) Statistical analysis showed that systemic administration of inhaled corticosteroids was an independent risk factor for Candida albicans infection in hospitalized patients. Conclusion Candida albicans is the main pathogen of Candida albicans infection in COPD patients. Regulating the use of systemic glucocorticoids and proper inhaled corticosteroids are the key factors to prevent Candida oralis infection in COPD patients.