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目的 研究凋亡抑制因子survivin在BTCC中的表达及其与肿瘤分级、分期、复发之间的关系。方法 采用免疫组化法 (ABC法 ) ,对 5 2例BTCC和 10例正常膀胱中survivin的表达情况进行检测 ,分析其在膀胱癌和非癌膀胱组织中的表达以及与肿瘤病理学分级、分期和患者复发情况的关系。结果 survivin的表达随BTCC的病理分级、分期的增高而相应增高 ,Ⅰ、Ⅱ、Ⅲ级中表达率分别为 6 0 .0 %、70 .8%、10 0 % ,浅表性 (Tis～T1)、浸润性 (T2 ～T4)中表达率分别为 4 3.5 %、93 1% ,初发BTCC、复发BTCC表达率为 5 9.4 %、90 .0 % (P <0 .0 5 )。结论 细胞凋亡抑制因子survivin在BTCC组织中表达上调 ,提示survivin可能通过抑制细胞凋亡 ,对BTCC的发生发展起重要作用 ;survivin随BTCC病理分级、分期增高而表达增高 ,并与肿瘤复发有关 ,survivin有可能作为判断分级、分期 ,监测复发的指标 ;survivin可能为膀胱癌基因治疗提供新的合理靶点。
Objective To study the expression of survivin in BTCC and its relationship with tumor grade, stage and recurrence. Methods The expression of survivin in 52 cases of BTCC and 10 cases of normal bladder was detected by immunohistochemistry (ABC method). The expression of survivin in bladder cancer and non-cancerous bladder was analyzed. The expression of survivin was correlated with tumor pathological grade, And the patient relapse situation. Results The expression of survivin increased with the increase of pathological stage and stage of BTCC. The expression rates of survivin in stage Ⅰ, Ⅱ and Ⅲ were 60.0%, 70.8%, 100%, and superficial (Tis ~ T1 ) And invasive (T2 ~ T4) were 43.5% and 93.1% respectively. The rates of primary BTCC and recurrent BTCC were 59.4% and 90.0% respectively (P <0.05). Conclusion The up-regulation of survivin in BTCC suggests that survivin may play an important role in the occurrence and development of BTCC by inhibiting cell apoptosis. Survivin is up-regulated along with the pathological grade and staging of BTCC, Survivin may be used as an index to judge the grade, stage and monitor recurrence. Survivin may provide a new rational target for bladder cancer gene therapy.