特发性阿狄森氏病患者双侧肾上腺皮质产生类固醇激素的细胞,因自身免疫病理而遭破坏,继而造成类固醇激素映乏。患者血清中存在着抗肾上腺皮质球状带细胞中富含微粒体酶亚细胞成份的特异抗体,但是有关该病特异性自身抗原的确切性质尚未弄清。作者设法揭示存在于特发性阿狄森氏病患 In idiopathic Addison’s disease, the cells that produce steroid hormones in the bilateral adrenal cortex are destroyed due to the autoimmune pathology, which in turn leads to the steroid hormone-induced deficiency. There are specific antibodies in human serum that are rich in microsomal enzyme subcellular components in the anti-adrenocortical globular cells, but the precise nature of the autoantigen specific for that disease has not yet been clarified. The authors sought to reveal the presence of idiopathic Addison’s disease