例1女，59岁。因无明确原因反复低热，全身肌肉酸痛、周身乏力、咳嗽1月余到我院内科就诊，未明确诊断。经抗炎及对症治疗不见好转，上述症状逐渐加重。3个月后出现全身多发性硬结，并有耳鸣和听力下降，且在短期内进展迅速。无外伤及耳毒药物应用史。在内分泌科住院检查结果： Example 1 Female, 59 years old. Because there is no clear reason for repeated low fever, muscle aches, whole body fatigue, coughing more than 1 month to our hospital medical treatment, not a clear diagnosis. After anti-inflammatory and symptomatic treatment did not improve, the above symptoms gradually increased. Three months after the onset of systemic multiple sclerosis, tinnitus and hearing loss, and rapid progress in the short term. No history of trauma and ototoxicity. In endocrinology inpatient examination results: