1964年Markham第一次报告碘化磷酰硫胆碱(echthiophate iodide)眼药水引起的全身毒性反应。国内外文献散见一些有关各种眼药水和眼药膏引起的全身反应,主要见于眼科学杂志,而其他各科医务人员很少注意到眼药引起的全身反应,其中包括一些不容易解释的心血管、肺、植物神经系统以及中枢神经系统症状。本文的目的是提醒其他各科医务人员注意。眼结膜囊内滴药后,可通过结膜毛细血管吸收到全身,也可通过鼻泪管进入口咽腔和胃肠道而被吸收。粘膜充血时吸收量更大,如用手指压迫泪囊部,全身 Markham first reported systemic toxicity response to echthiophate iodide eye drops in 1964. Some domestic and foreign literature about some systemic reactions caused by various eye drops and ophthalmic ointments are mainly found in ophthalmology magazines, while other medical staff rarely pay attention to the systemic reactions caused by ophthalmic drugs, including some not easy to explain the heart Blood vessels, lungs, autonomic nervous system and central nervous system symptoms. The purpose of this article is to remind other medical staff. After the conjunctival sac drops, through the conjunctiva capillaries can be absorbed into the body, but also through the nasolacrimal duct into the oropharyngeal cavity and the gastrointestinal tract is absorbed. Mucosal congestion when absorbed more, such as the pressure of the lacrimal sac with your fingers, the whole body