论文部分内容阅读
目的:观察脑转移瘤放射治疗局部推量的疗效。方法:回顾性分析63例进行放射治疗脑转移瘤病人,采用6MeV-X线,两侧平行相对野作全脑照射,临床靶体积(CTV)包括肿瘤靶体积(GTV)及周围水肿区,处方剂量为30~40Gy,分割次数为10~20次。其中27例缩野后局部推量20Gy。分析常规处方剂量后进行局部推量与未进行局部推量的两个组别局部区域复发率(LRR)、总生存率(OS)和KPS评分改变的差别。结果:中位随访6个月。局部推量组和未局部推量组的LRR分别为18.5%(5/27)和27.8%(10/36);局部推量组和未局部推量组的OS分别为85.2%(23/27)和77.8%(28/36);局部推量组和未局部推量组的KPS>=70分别为18和19。结论:脑转移瘤常规处方剂量放疗后进行局部推量对脑转移瘤的局部控制率及KPS评分有益。
Objective: To observe the curative effect of local dose of radiotherapy for brain metastases. Methods: Sixty-three patients with brain metastases undergoing radiation therapy were retrospectively analyzed. The 6MeV-X lines were used to illuminate the brain. The clinical target volume (CTV) including tumor target volume (GTV) and surrounding edema area Dose is 30 ~ 40Gy, the number of divisions is 10 ~ 20 times. Among them, 27 cases of contracted local volume 20Gy. The difference between LRR, OS, and KPS scores of the two groups after the local prescription dose was analyzed after the conventional prescription dose was compared. Results: The median follow-up of 6 months. The LRR was 18.5% (5/27) and 27.8% (10/36) in the local and non-local thrust groups respectively, and 85.2% (23/27) and 77.8% in the local and non-local thrust groups respectively (28/36). The KPS> = 70 for the local and non-local thrust groups were 18 and 19, respectively. CONCLUSION: Local delivery of brain metastases with conventional prescription dose after radiotherapy is beneficial to the local control rate of brain metastases and KPS score.