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目的 探讨奥美拉唑 (Omeprazole)、羟氨苄青霉素 (Amoxycillinum)和甲硝唑 (Metronidazole)一周短程疗法根除幽门螺杆菌 (Hp)的疗效 ,对Hp相关性活动期十二指肠溃疡 (DU)治疗效果和复发的影响 ,并与两周疗法相比较。方法 将 12 8例Hp阳性的活动期DU患者随机分成两组 ,A组 :奥美拉唑 2 0mg、羟氨苄青霉素 10 0 0mg、甲硝唑40 0mg ,每日 2次 ,共 1周 ,奥美拉唑 2 0mg,每日 1次 ,共 4周 ;B组 :奥美拉唑 2 0mg、羟氨苄青霉素 10 0 0mg、甲硝唑40 0mg ,每日 2次 ,共 2周 ,奥美拉唑 2 0mg ,每日 1次 ,共 4周。治疗前和治疗后 1月、1年各做 1次电子胃镜检查 ,并取活组织做快速尿素酶和Warthin -Starry银染色检查Hp。结果 A、B两组Hp根除率分别为 92 19% (5 9/ 6 4)、95 31% (6 1/ 6 4) (P >0 0 5 ) ;DU治愈率 93 76 % (6 0 / 6 4) ,96 88% (6 2 / 6 4) (P >0 0 5 ) ;副作用发生率 4 6 9% (3/ 6 4)、12 5 0 % (8/ 6 4) (P <0 0 1)。Hp根除与否 1年后DU复发率 3 33% (4 / 12 0 )、75 0 0 % (6 / 8) ,(P <0 0 1)。结论 以奥美拉唑为主 ,合并羟氨苄青霉素和甲硝唑治疗Hp相关性DU、Hp清除率和DU治愈率高 ,并能有效预防DU复发。 1周短程疗法即可达到治疗目的 ,副作用小 ,顺应性好 ,可以取代 2周疗法 ,是
Objective To investigate the curative effect of one-week short-course therapy of Omeprazole, Amoxycillinum and Metronidazole on Helicobacter pylori (Hp) in Hp-related active duodenal ulcer (DU) Therapeutic and relapse effects were compared with two-week treatment. Methods One hundred and twenty-eight Hp positive active DU patients were randomly divided into two groups: group A: omeprazole 20 mg, amoxicillin 100 mg and metronidazole 40 mg twice daily for 1 week. Group B: omeprazole 20mg, amoxicillin 100mg, metronidazole 40mg, 2 times a day for 2 weeks, Omejila Azole 2 0mg, 1 day, a total of 4 weeks. Before treatment and after treatment for 1 month, 1 year each done a gastroscopy, and take the living tissue to do rapid urease and Warthin -Starry silver staining Hp. Results The eradication rates of Hp in group A and group B were 92 19% (59/6 4) and 95 31% (61/64), respectively (P 0 05). The cure rate of DU was 93 76% The incidence of side effects was 46.9% (3/6 4), 125.0% (8/64) (P <0), 96 88% (62/64) 0 1). The recurrence rate of DU after 3 years was 3 33% (4/12 0) and 75 0 0% (6/8), respectively (P 0 01). Conclusions Omeprazole is the mainstay of the treatment of Hp-associated DU with combination of amoxicillin and metronidazole. Hp clearance rate and DU cure rate are high, and can effectively prevent DU recurrence. 1 week short-course therapy to achieve the purpose of treatment, side effects, good compliance, can replace the 2-week treatment is