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目的 观察细胞凋亡相关基因P_(53),Bcl—2在外阴鳞癌组织中的表达,研究其与外阴鳞癌临床病理诸因素的关系。方法 采用免疫组化S—P法对30例外阴鳞癌进行检测。结果 外阴鳞癌中P_(53)表达率随病理分级的降低,临床分期的增高而增高,P_(53)表达率高的肿瘤易发生淋巴结转移。Bcl—2的阳性表达率随病理分级的降低而降低,与临床分期无关。Bcl—2的表达率在淋巴结转移组明显降低(P<0.05)。P_(53)的阳性表达与Bcl—2的阳性表达呈明显的负相关。结论 凋亡相关差因P_(53)及Bcl—2在外阴鳞癌的发展中起一定作用,联合检测P_(53)及Bcl—2对估计外阴鳞癌患者的预后有一定价值。
Objective To observe the expression of apoptosis-related genes P53 and Bcl-2 in vulvar squamous cell carcinoma and to study their relationship with the clinicopathological factors of vulvar squamous cell carcinoma. Methods 30 cases of vulvar squamous cell carcinoma were detected by immunohistochemical S-P method. Results The expression of P_ (53) in vulvar squamous cell carcinoma was decreased with the pathological grading and the clinical stage increased. Lymph node metastasis was easily found in tumors with high P_ (53) expression. The positive rate of Bcl-2 decreased with the decrease of pathological grade, but not with clinical stage. The expression of Bcl-2 was significantly lower in lymph node metastasis (P <0.05). The positive expression of P_ (53) was negatively correlated with the positive expression of Bcl-2. Conclusions Apoptosis-related differences play an important role in the development of vulvar squamous cell carcinoma because P_ (53) and Bcl-2 may play a role in the prognosis of patients with vulvar squamous cell carcinoma.