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作者发现有一些病人在吸入支气管扩张药异丙托溴铵(lpratropium bromide)气雾剂(商品名Atrovent)后,可出现反常的支气管收缩作用。Atrovent内含防腐剂苯扎氯铵(洁而灭)0.25 g/L和依地酸0.5 g/L。为弄清该制剂产生反常药理作用的原因,作者做了以下试验: 22例稳定型哮喘病人,第1期试验给予受试病人吸入atrovent单剂4 ml,测定受试者在吸药前、后的最大呼气容量(FEV_1)。挑选吸药后FEV_1降低幅度超过20%的受试者继续试验。第2期试验按单盲法给予受试者
The authors found that some patients developed an abnormal bronchoconstriction after inhaling the bronchodilator lpratropium bromide aerosol (trade name Atrovent). Atrovent contains preservative benzalkonium chloride (clean and off) 0.25 g / L and edetic acid 0.5 g / L. In order to clarify the reasons for the abnormal pharmacological effects of the preparation, the authors did the following: 22 patients with stable asthma, the first trial to patients in the test inhaled atrovent a single dose of 4 ml, the determination of subjects in the medication before and after Of the maximum expiratory volume (FEV_1). Subjects who chose to reduce FEV_1 by more than 20% after drug inhalation continued the trial. The second trial was administered by single blinded test