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本文对19例子宫平滑肌良性肿瘤进行了细胞遗传学研究,4例的克隆细胞涉及12号染色体异常,15例有正常核型。作者分析了21例经外科切除子宫肌瘤病人的肿瘤标本,病理组织学诊断均为良性平滑肌瘤。按照Limon 等的方法进行孵化和处理,获得了19例适合的细胞分裂中期相,其中4例染色体畸变如下。例2:在26个细胞分裂中期相中,有22个为46条染色体,伴有 t(X;12)(p22.3,q15)。例10:28个细胞分裂中期相的24个有48条染色体。额外的染色体是 del(2)(p22)和12号染色体。剩余的4个细胞分裂中期相为正常核型。
In this paper, 19 cases of uterine smooth muscle benign tumors were studied in cytogenetics, 4 cases of cloned cells involved in chromosome 12 anomalies, 15 cases of normal karyotype. The authors analyzed 21 cases of patients with surgical removal of uterine fibroids tumor specimens, histopathological diagnosis of benign leiomyoma. According to the method of Limon et al., Hatching and processing, 19 suitable mitotic metaphases were obtained, of which 4 were chromosomal aberrations. Example 2: Of the 26 metaphases, 22 were 46 chromosomes with t (X; 12) (p22.3, q15). Example 24 There are 48 chromosomes in 24 of 24 metaphases. Additional chromosomes are del (2) (p22) and chromosome 12. The remaining four cell metaphases are normal karyotypes.