论文部分内容阅读
目的:观察榄香烯联合紫杉醇化疗方案治疗晚期非小细胞肺癌患者的临床疗效。方法:采取随机分组法将84例晚期非小细胞肺癌患者分为治疗组和对照组。治疗组44例给予榄香烯联合紫杉醇化疗;对照组40例给予单纯紫杉醇化疗,21天为一个周期,观察4个周期。治疗前后分别进行血常规、肝肾功能、胸CT扫描等指标检查,观察肿瘤病灶大小变化,同时记录临床症状变化及化疗毒副反应。结果:治疗组和对照组癌灶总有效率分别为29.54%和17.50%,两组间存在显著性差异(P<0.05)。在不良反应方面,骨髓抑制及及肝功能变化治疗组均显著优于对照组(P<0.01)。消化道反应及肾功能变化两组差异不明显。结论:榄香烯联合化疗治疗晚期非小细胞肺癌的疗效较单纯化疗好,可减轻化疗毒副反应,提高患者的生存质量。
Objective: To observe the clinical efficacy of elemene combined with paclitaxel in the treatment of advanced non-small cell lung cancer patients. Methods: Eighty-four patients with advanced non-small cell lung cancer were randomly divided into treatment group and control group. In the treatment group, 44 patients were given elemene combined with paclitaxel chemotherapy; 40 patients in the control group were treated with paclitaxel alone, 21 days were one cycle and 4 cycles were observed. Before and after treatment were blood tests, liver and kidney function, chest CT scan and other indicators to check the size of tumor lesions change, while recording changes in clinical symptoms and chemotherapy toxicity. Results: The total effective rates of treatment group and control group were 29.54% and 17.50% respectively, there was significant difference between the two groups (P <0.05). Adverse reactions, bone marrow suppression and liver function changes were significantly better than the control group (P <0.01). Gastrointestinal reactions and changes in renal function was not significantly different between the two groups. Conclusion: The effect of elemene combined with chemotherapy in the treatment of advanced non-small cell lung cancer is better than that of chemotherapy alone, which can reduce the side effects of chemotherapy and improve the quality of life of patients.