Maspin最早是从正常乳腺上皮细胞和乳腺癌中采用消减杂交技术分离出来的,是一种候选肿瘤抑制基因。研究表明,Maspin对肿瘤细胞的运动、侵袭、转移、抗血管新生和诱导凋亡等有抑制作用。p53是迄今发现与人类恶性肿瘤相关性最高的抑癌基因。Maspin的启动子区域存在一个p53结合位点,p53可直接结合到该位点进行调节,从而控制其mRNA的表达。现就Maspin和p53的结构、在卵巢癌中的表达,以及两者表达的相关性予以综述。 Maspin, originally isolated from normal breast epithelial cells and breast cancer using subtractive hybridization, is a candidate tumor suppressor. Studies have shown that Maspin can inhibit tumor cell movement, invasion, metastasis, anti-angiogenesis and apoptosis induction. p53 is by far the most relevant tumor suppressor gene found in human malignancies. Maspin promoter region has a p53 binding site, p53 can be directly bound to the site for regulation, in order to control its mRNA expression. Maspin and p53 are now on the structure, expression in ovarian cancer, as well as the correlation between the expression of the two are reviewed.