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目的:分析晚期原发性胆汁性肝硬化(PBC)患者外周血调节性T细胞表达。方法:连续选择前来我院门诊就诊及住院的PBC患者43例,根据Harada方法进行临床分期:早期组(I和Ⅱ期,17例),晚期组(Ⅲ和Ⅳ期,26例),两组对象均接受了外周血调节性T细胞(CD4+CD25+Treg和CD4+CD25+Foxp3+Treg检测,并与同期体检结论健康者(对照组,19例)相同测试结果比较。结果:早、晚期PBC患者外周血CD4+CD25+Treg和CD4+CD25+Foxp3+Treg表达水平均明显低于对照组,同时晚期PBC患者外周血CD4+CD25+Treg和CD4+CD25+Foxp3+Treg表达水平也明显低于早期PBC组(P均<0.05~0.01)。结论:晚期PBC患者存在明确的外周血调节性T细胞低水平表达。
Objective: To analyze the expression of regulatory T cells in peripheral blood in patients with advanced primary biliary cirrhosis (PBC). Methods: Forty-three patients with PBC who came to our hospital for outpatient clinic and hospitalization were selected according to the Harada method. The clinical stage was as follows: early stage (stage I and stage II, 17 cases), late stage (stage III and stage IV, 26 cases) (CD4 + CD25 + Treg and CD4 + CD25 + Foxp3 + Tregs) were measured and compared with the same test results in healthy subjects (control group, 19 cases) at the same period.Results: The expression levels of CD4 + CD25 + Treg and CD4 + CD25 + Foxp3 + Treg in peripheral blood of patients with advanced PBC were significantly lower than those in control group, and the levels of CD4 + CD25 + Treg and CD4 + CD25 + Foxp3 + Treg in peripheral blood of advanced PBC patients were also significantly higher (P <0.05-0.01) .Conclusion: There is a clear expression of peripheral blood regulatory T cells in advanced PBC patients.