【摘 要】
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Interleukin-18 (IL-18) is a novel proinflammatory cytokine with potent interferon (IFN)-γ inducing activity that plays an important biological role in the enha
【机 构】
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Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
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Interleukin-18 (IL-18) is a novel proinflammatory cytokine with potent interferon (IFN)-γ inducing activity that plays an important biological role in the enhancement of the activity of natural killer cells and cytotoxic T lymphocytes. In this study, we have identified a novel short form of IL- 18 in mouse, named IL-18s. IL-18s might be an alteative splicing variant of IL-18 and its cDNA contains a 57 bp in-frame deletion. Like IL-18, IL-18s is also widely expressed in mouse tissues. It was suggested that IL-18s might have a caspase-1-dependent mechanism for maturation and secretion similar to that of IL-18: when transfected in COS-7 cells, pro-IL-18s (22 kDa) could be detected, and the mature IL-18s (16 kDa) could also be detected when combined with caspase-1. We observed that recombinant mouse IL-18s did not show any IL-18-like function, and IL-18s could enhance the ability of IL-18 to increase IFN-γ production by approximately 40%in mouse splenocytes. This effect was observed primarily at relative low concentrations of IL- 18, suggesting that IL-18s might regulate the activity of IL-18 in the physiological conditions.
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