本文报道了Sulzbefger对迟发型过敏性反应机理的毕生探讨。作者综述了近5年来的研究指出:表皮郎格罕细胞对许多皮肤免疫反应起着关键性作用;角朊细胞在表皮免疫功能中也起作用,它们分泌出调节各型皮肤反应的某些因子。这类细胞和某些因子与淋巴样细胞之间的相互作用表明,皮肤应看作是一个免疫器官。 Sulzberger在1979年7月重申了“外周性致敏作用”的概念,因为皮内注射致敏物质比肌肉内、腹膜内等注射所诱发致敏性的潜力更大。显然,皮内沉积物与皮肤蛋白有更高的结合机率。Sulzberger的结论是:皮肤作为致敏器官和被致敏器官,在致敏过程中具有某种特殊的独立地位。作者等的研究也 This article reports the lifetime study of Sulzbefger’s mechanism of late-onset hypersensitivity reaction. The authors summarize the findings of the past five years: Epidermal Langerhans cells play a key role in many skin immune responses; keratinocytes also play a role in the immune function of the epidermis, which secrete certain factors that regulate various types of skin reactions . The interaction of these cells and certain factors with lymphoid cells suggests that the skin should be considered as an immune organ. Sulzberger reiterated the concept of “peripheral sensitization” in July 1979, as the potential for sensitization induced by intradermal injections of sensitizers is greater than injections injected intramuscularly, intraperitoneally, and the like. Obviously, intradermal deposits and skin proteins have a higher probability of binding. Sulzberger’s conclusion is: the skin as sensitized organs and sensitized organs, in the sensitization process has a special kind of independent status. The study of the authors too