多年来人们就已知道维生素D(V_D)的生物效应,它能促进钙在肠道中的吸收,动员骨骼中的无机盐,促进骨骼的矿化作用,因此它可以治疗营养性佝偻病和骨质软化病。但是当时人们还不知道这是由于V_D的直接作用,还是由于它变成了具有这种活性的代谢物的作用。慢性肾功衰竭,促使人们在V_D代谢领域进行了大量的研究。这种病人表现有V_D缺乏症状,而且需要用大剂量的这种维生素来治疗才能纠正其中的一些异常。虽然对这种“V_D耐受状态”的本质还不清楚,但是无疑地可以提出这种可能性, It has been known for many years that the biological effect of vitamin D (V_D), which promotes the absorption of calcium in the gut, mobilizes inorganic salts in bones and promotes the mineralization of bones, can therefore treat nutritional rickets and osteomalacia disease. But at that time, it was not yet known whether this was due to the direct effect of V_D or because it became a metabolite with this activity. Chronic renal failure, prompting people in the field of V_D has conducted a lot of research. This patient presents with symptoms of V_D deficiency and needs to be treated with high doses of this vitamin to correct some of these abnormalities. Although the nature of this “V_D-tolerant state” is unclear, it is doubtless possible to raise this possibility,