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目的研究大肠癌患者血清可溶性白细胞介素－２受体（ｓＩＬ－２Ｒ）和肿瘤坏死因子（ＴＮＦ）变化的临床意义．方法采用双抗体夹心ＥＬＩＳＡ法对７６例大肠癌患者手术前后血清ｓＩＬ－２Ｒ和ＴＮＦ水平进行检测，其中根治性手术４８例，姑息性手术２８例，以４０例献血员为正常对照组．结果大肠癌患者血清ｓＩＬ－２Ｒ（Ｕ／Ｌ）和ＴＮＦ（ｐｇ／Ｌ）分别为６０３６±９４３和９６２±９１，明显高于正常对照组的２０８３±７９６和２５１±４７（Ｐ＜００１），两者的增高与大肠癌Ｄｕｋｅ分期及手术方式不同密切相关．结论动态观察血清ｓＩＬ－２Ｒ和ＴＮＦ的变化，可作为大肠癌诊断、评价疗效及监测预后的参考指标．
Objective To study the clinical significance of serum soluble interleukin-2 receptor (sIL-2R) and tumor necrosis factor (TNF) in patients with colorectal cancer. Methods Serum sIL-2R and TNF levels were measured in 76 patients with colorectal cancer before and after operation by double-antibody sandwich ELISA. Among them, 48 cases were radical surgery, 28 cases were palliative surgery, and 40 cases were normal controls. Results Serum sIL-2R (U/L) and TNF (pg/L) were 6036±943 and 962±91 in patients with colorectal cancer, which were significantly higher than those of 2083±79 in normal control group. 6 and 251±47(P<001), both of which are closely related to the different stages of Duke colorectal cancer and surgical methods. Conclusion Dynamic observation of serum sIL-2R and TNF changes can be used as a reference index for the diagnosis, evaluation of curative effect and monitoring of prognosis of colorectal cancer.