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目的探讨肝硬化患者血清中载脂蛋白A-I(aPoA-I)和载脂蛋白B(aPoB)与肝炎肝硬化的关系及临床意义。方法对2006年4月—2009年6月于清苑县人民医院就诊的52例患者和26例健康体检者同时测定血清中aPoA-I和aPoB的水平,并进行比较。结果肝硬化代偿组、失代偿组血清中aPoA-I和aPoB均明显低于对照组,差异有统计学意义(均P<0.01)。肝硬化Child-pugh分级级别越高,血清中aPoA-I和aPoB下降水平越明显。结论血清中aPoA-I和aPoB的水平降低与肝硬化及肝硬化Child-pugh分级关系密切。对判断肝硬化患者病情及预后有重要参考意义。
Objective To investigate the relationship between serum apolipoprotein A-I (aPoA-I) and apolipoprotein B (aPoB) and hepatitis cirrhosis in patients with cirrhosis and its clinical significance. Methods Serum levels of aPoA-I and aPoB in 52 patients and 26 healthy controls from April 2006 to June 2009 in Qingyuan County People’s Hospital were measured and compared. Results The levels of serum aPoA-I and aPoB in decompensated and decompensated groups were significantly lower than those in control group (all P <0.01). The higher the Child-pugh cirrhosis classification level, the more the level of serum aPoA-I and aPoB declines. Conclusion Serum levels of aPoA-I and aPoB are closely related to Child-pugh classification of cirrhosis and cirrhosis. It has important reference value for judging the condition and prognosis of patients with cirrhosis.