肝纤维化是各种慢性肝病发展成肝硬化的必经阶段,是各种致病因子引起的肝脏损伤和炎症,导致纤维组织广泛增生和沉积。其本质是由于肝细胞外基质(extracelluer matrix,ECM)合成与降解不平衡导致ECM过度沉积的病理过程,也是肝细胞损伤后修复的机制[1],是各种慢性肝病共同的病理变 Liver fibrosis is a necessary stage for the development of various chronic liver diseases into cirrhosis. It is a liver injury and inflammation caused by various pathogenic factors, resulting in extensive proliferation and deposition of fibrous tissue. Its essence is due to the imbalance of synthesis and degradation of extracellular matrix (ECM) leading to over-deposition of ECM pathological process is also a mechanism of liver cell injury repair [1], is a common pathological changes in a variety of chronic liver disease