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儿童恶性肿瘤中以白血病的发病率为最高。随着科学的进步,小儿白血病治疗效果也不断提高,急性淋巴细胞性白血病国外5年以上生存率已达50％,但急性非淋巴细胞性白血病来势凶、发展快、治疗困难、死亡率仍较高。国内少数医院试用维甲酸(reti-noic acid,RA)治疗急性早幼粒细胞性白血病(简称APL),取得了较好的疗效。我科收治一名APL病儿,用多种化疗方案治疗4个多月无效,后改用维甲酸治疗29天,达到完全缓解。现报告如下:
The highest incidence of leukemia in children with malignant tumors. With the progress of science, the therapeutic effect of pediatric leukemia has been continuously improved. The survival rate of acute lymphoblastic leukemia has reached 50% in more than 5 years abroad, but the acute non-lymphocytic leukemia is fierce, develops rapidly, the treatment is difficult, the mortality rate is still higher high. A small number of domestic hospitals trial of retinoic acid (reti-noic acid, RA) for the treatment of acute promyelocytic leukemia (APL), and achieved good results. Our department treated an APL sick child, with a variety of chemotherapy regimens for more than 4 months, after treatment with retinoic acid for 29 days, to achieve complete remission. The report is as follows: