The adjustment of primary hydrocarbon reservoirs in marine formations is an important feature of the oil pools in the Tarim Basin. Large-scale hydrocarbon adjustment is related to the strong regional tectonic movements, which is always accompanied by extensive migration of basin fluids including diagenetic and mineralizing fluids. Organic fluid inclusions are well developed in hydrothermal minerals, such as fluorite, which have been found in the dissolution-enlarged fractures or karstification caves in the Ordovician in the central Tarim Basin. Proved by well drilling, the fluorite deposit is good reservoir for oil and gas. So the peculiar accompanied or superimposed relationship between fluorite hydrothermal fluid mineralization and hydrocarbon migration and accumulation exists in the Ordovician in the central Tarim Basin. Considering regional tectonic setting and mineralization condition, through different kinds of analytic methods including electron spin resonance dating, fluid inclusion laser Raman and colonial inclusions hydrocarbon fossil analysis, we proposed that extensive mineralizing fluids and hydrocarbon migration occurred in late Yanshan-Himalayan (110.4―30.8 Ma) period, and Himalayan, especially, is an important period for hydrocarbon accumulation from 34.3 Ma to present. The adjustment of primary hydrocarbon reservoirs in marine formations is an important feature of the oil regional pools in the Tarim Basin. Which is always important by extensive migration of basin fluids including diagenetic and mineralizing fluids. Organic fluids inclusions are well developed in hydrothermal minerals, such as fluorite, which have been found in the dissolution-enlarged fractures or karstification caves in the Ordovician in the central Tarim Basin. Proved by well drilling, the fluorite deposit is good reservoir for oil and gas. So the peculiar accompanied or superimposed relationship between fluorite hydrothermal fluid mineralization and hydrocarbon migration and accumulation exists in the Ordovician in the central Tarim Basin. Considering regional tectonic setting and mineralization condition, through different kinds of analytic methods including electron spin resonance dating , fluid incl usion laser Raman and colonial inclusions hydrocarbon fossil analysis, we proposed that extensive mineralizing fluids and hydrocarbon migration occurred late in Yanshan-Himalayan (110.4-30.8 Ma) period, and Himalayan, especially, is an important period for hydrocarbon accumulation from 34.3 Ma to present .