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应用基因重组肝细胞生长因子（HGF）可诱导人肺癌细胞运动和侵袭，通过细胞离散、集落扩散和基底膜侵袭实验证明，侵袭抑制因子-2（ⅡF-2）可明显地抑制由HGF诱导的作用。该抑制作用可被抗ⅡF-2抗体所阻断，表明ⅡF-2在肿瘤转移的预防和治疗方面可能具有重要意义。
Recombinant hepatocyte growth factor (HGF) gene can induce the movement and invasion of human lung cancer cells. It was proved by cell dispersion, colony proliferation and basement membrane invasion assay that invasion inhibitory factor-2 (IIF-2) can significantly inhibit the induction by HGF. effect. This inhibition can be blocked by anti-IIF-2 antibodies, suggesting that IIF-2 may have important implications in the prevention and treatment of tumor metastasis.