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目的:探讨代谢综合征(MS)的非酒精性脂肪肝病(non-alcoholic fatty liver disease,NAFLD)和血管性勃起功能障碍(Erectile dysfunction,ED)的危险因素。方法:从2008～2009年北方城市健康体检人群中随机整群抽样资料完整者18 096例为研究对象,并分析探讨NAFLD和ED的危险因素。结果:本次研究对象为18 096例,年龄18～76岁,平均(46.8±10.1)岁。男10 096例(55.79%),女8 000例(44.21%)。MS知晓率为8.33%;成年健康体检者MS的患病率为21.18%。MS最常见的成分依次是高尿酸血症(27%,4838/18096)、肥胖和超重(21%)、高血压(20%)和血脂异常(17%)。MS各亚组的人体质量指数(BMI,kg/m2)和腰臀比(WHR)从高到低分别依次为ED[(28.9±1.1)、(1.26±0.03)]、超重或肥胖[(27.5±2.3)、(1.31±0.03)]、糖尿病前期[(26.8±2.6)、(1.03±0.03)]和高血压[(26.1±1.3)、(0.90±0.04)]。MS伴发NAFLD 3721例,患病率为20.56%;以MS伴发的NAFLD为因变量,Logistic回归分析显示:ALT升高、腰围、年龄、DM家族史、LDL-C、BMI(依次β=1.004～0.479,P=0.000～0.016)等为NAFLD的危险因素,体育锻炼和职业性体力劳动为其保护因素。ED106例,患病率为1.04%;Logistic回归分析显示:年龄、腰围、LDL-C、DM家族史、BMI(依次β=0.681～0.238,P=0.000～0.018)等为ED的危险因素,文化程度、体育锻炼和职业性体力劳动为其保护因素。结论:MS合并的NAFLD和ED的危险因素与MS关系密切,针对MS危险因素的矫正是预防和治疗NAFLD,ED的新途径。
Objective: To explore the risk factors of non-alcoholic fatty liver disease (NAFLD) and erectile dysfunction (ED) in metabolic syndrome (MS). Methods: From 2008 to 2009, 18 096 complete random sample of healthy urban population from northern cities were selected as the research subjects, and the risk factors of NAFLD and ED were analyzed. Results: The study population was 18 096 cases, aged from 18 to 76 years, with an average of (46.8 ± 10.1) years. There were 10 096 (55.79%) males and 8 000 females (44.21%) males. The awareness rate of MS was 8.33%. The prevalence of MS in adult healthy subjects was 21.18%. The most common components of MS were hyperuricemia (27%, 4838/18096), obesity and overweight (21%), hypertension (20%) and dyslipidemia (17%). The body mass index (BMI, kg / m2) and waist-to-hip ratio (WHR) of MS subgroups were ED [(28.9 ± 1.1), (1.26 ± 0.03)], ± 2.3, 1.31 ± 0.03), pre-diabetes (26.8 ± 2.6, 1.03 ± 0.03) and hypertension (26.1 ± 1.3, 0.90 ± 0.04), respectively. MS associated with NAFLD 3721 cases, the prevalence was 20.56%; NAFLD associated with MS as a dependent variable, Logistic regression analysis showed: ALT, waist circumference, age, DM family history, LDL-C, BMI 1.004 ~ 0.479, P = 0.000 ~ 0.016) were risk factors for NAFLD, physical exercise and occupational physical labor as their protective factors. ED106 cases, the prevalence was 1.04%; Logistic regression analysis showed that: age, waist circumference, LDL-C, family history of DM, BMI (followed by β = 0.681-0.238, P = 0.000-0.018) Degree, physical exercise and occupational physical labor as their protective factors. Conclusion: The risk factors of MS combined with NAFLD and ED are closely related to MS. The correction of MS risk factors is a new way to prevent and treat NAFLD and ED.