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应用二维超声心动图(2DE)评价11只犬在定量心肌缺血时的局部左室收缩功能(RLVF)与整体左心泵功能(TLVF)。结果显示:随着冠脉狭窄,左室舒张末期面积和左室收缩末期面积都有增加(P<0.01),左室面积喷射分数(LVAEF)从56％减低到36％(P<0.01)。轻度心肌缺血时,RLVF明显异常,局部室壁运动异常的圆周范围(CERWMA)小于40％。中度心肌缺血,除RLVF异常外,LVAEF出现异常,CERWMA小于50％,TLVF无明显变化。重度心肌缺血,CERWMA大于50％,TLVF出现明显异常。局部室壁运动异常是检测心肌缺血敏感和特异的技术,RLVF变化明显早于TLVF。同时,CERWMA和心肌灌注缺血区相关较好,为临床负荷超声心动图检测暂时性心肌缺血提供了实验依据。
Two-dimensional echocardiography (2DE) was used to evaluate the local left ventricular systolic function (RLVF) and global left ventricular pump function (TLVF) during quantitative myocardial ischemia in 11 dogs. The results showed that left ventricular end-diastolic area and left ventricular end-systolic area increased with coronary artery stenosis (P <0.01) and left ventricular ejection fraction (LVAEF) decreased from 56% to 36% (P <0.01). In mild myocardial ischemia, RLVF was significantly abnormal and the circumferential extent of local wall motion (CERWMA) was less than 40%. Moderate myocardial ischemia, in addition to RLVF abnormalities, abnormal LVAEF, CERWMA less than 50%, TLVF no significant change. Severe myocardial ischemia, CERWMA greater than 50%, TLVF significant abnormalities. Local wall motion abnormalities is a sensitive and specific technique for detecting myocardial ischemia, RLVF changes significantly earlier than TLVF. At the same time, CERWMA and myocardial perfusion ischemia area is good, providing experimental evidence for clinical load echocardiography detection of transient myocardial ischemia.