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气管的一些良性或恶性病变从理论上说是可以通过简单的手术切除,并将断端进行端端吻合来治疗的。然而这仅限于病损长度不超过成人气管长度的50%、小孩气管长度的30%。对大多患者而言,可以进行气管移植替代。然而气管移植有诸多问题有待解决,例如免疫排斥、再血管化、感染、肉芽组织增生等方面的问题。本文主要针对如何用不同的降低免疫排斥反应的方法来阐述免疫排斥反应在同种异体气管移植物领域的研究进展及应用现状。
Tracheal some benign or malignant lesions theoretically can be treated by a simple surgical resection, and end-to-end anastomosis to treat. However, this is limited to the fact that lesion length does not exceed 50% of adult tracheal length and 30% of child tracheal length. For most patients, tracheal replacement can be performed. However, tracheal transplantation has many problems to be solved, such as immune rejection, revascularization, infection, granulation tissue proliferation and other issues. This article focuses on how to use different ways to reduce immune rejection to elucidate the progress of immunological rejection in the field of allograft tracheal transplantation and its application status.