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目的探讨大Y染色体核型的临床意义。方法采用外周血淋巴细胞培养及G显带技术对患者行细胞遗传学检查。结果在检出的376例大Y染色体核型患者中有101例其妻有流产史、98例不育、82例其妻曾生育缺陷儿、29例无精子、15例其妻有死胎史、11例为小睾等。结论大Y染色体核型可能有一定的临床效应。
Objective To investigate the clinical significance of large Y chromosome karyotype. Methods Peripheral blood lymphocyte culture and G-banding technique were used to detect cytogenetics in patients. Results Of the 376 cases with large Y chromosome karyotypes, 101 had their own wives with history of miscarriage, 98 had infertility, 82 had his wife had childbirth defects, 29 had no sperm, 15 had his wife had a stillbirth history, 11 cases of small testicles. Conclusion Large Y chromosome karyotype may have some clinical effect.