喉癌作为恶性实体肿瘤,化学药物疗法在其综合治疗中扮演着日益重要的角色,但多药耐药(MDR)的产生成为导致化疗失败的主要原因。研究表明,多药耐药基因蛋白P-gp和ABCG2在喉癌的MDR中起着重要作用,P-gp和ABCG2之间或正或负呈相关性,其相关信号通路(M APK)与P-gp和ABCG2在肿瘤中的表达也有一定的相关性,但其调控因素及如何由此提高化疗效果有待进一步研究。 As a malignant tumor, laryngeal cancer plays an increasingly important role in its comprehensive treatment. However, the development of multidrug resistance (MDR) is the main reason for the failure of chemotherapy. Studies have shown that multidrug resistance gene proteins P-gp and ABCG2 play an important role in the MDR of laryngeal carcinoma. There is a positive or negative correlation between P-gp and ABCG2, and the correlation between the signaling pathways (M APK) and P- The expression of gp and ABCG2 also have a certain correlation in the tumor, but its regulatory factors and how to improve the effect of chemotherapy remains to be further studied.