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目的:研究氟伐他汀对老年高胆固醇血症的治疗效果并与辛伐他汀比较。方法:采用随机、单盲的方法,68例老年高胆固醇血症患者随机分为两组,服药前及服药后4周、8周测定血脂(胆固醇、甘油三酯),同时测血尿素氮、肌酐、ALT、肌酸激酶和血糖。结果:治疗后4周TC分别降低了23.2%和22.1%;降低LDL-C分别是29.1%和28.2%作用相似;氟伐他汀明显降低血清TG水平19.2%;载脂蛋白(APO)A1分别增加了13.1%和12.2%;APOB水平分别下降8.1%和7.0%;分别使脂蛋白A(LPa)水平降低了31.1%和24.4%;治疗8周后的疗效与4周比较无明显差异。结论:氟伐他汀治疗老年高胆固醇血症能显著降低Ⅱa和Ⅱb型高胆固醇血症患者TC、LDL-C,其作用与辛伐他汀相等;氟伐他汀降低TG作用优于辛伐他汀。
Objective: To study the therapeutic effect of fluvastatin on senile hypercholesterolemia and to compare with simvastatin. Methods: Sixty-eight elderly patients with hypercholesterolemia were randomly divided into two groups. Before treatment and 4 weeks after taking the drug, blood lipids (cholesterol, triglyceride) were measured at 8 weeks. At the same time, blood urea nitrogen, Creatinine, ALT, creatine kinase and blood sugar. Results: The levels of TC decreased by 23.2% and 22.1% respectively at 4 weeks after treatment. The effects of lowering LDL-C were similar at 29.1% and 28.2% respectively. Fluvastatin significantly reduced serum TG level by 19.2% and apolipoprotein (APO) A1 increased 13.1% and 12.2% respectively; the levels of APOB decreased 8.1% and 7.0% respectively; the levels of lipoprotein A (LPa) were decreased by 31.1% and 24.4% respectively; there was no significant difference between the 4 weeks and 8 weeks after treatment. Conclusion: Fluvastatin treatment of senile hypercholesterolemia can significantly reduce type Ⅱ a and Ⅱ b hypercholesterolemia in patients with TC, LDL-C, its role and simvastatin is equal; fluvastatin lower TG effect than simvastatin.