粉防己碱为一源于植物的钙通道阻滞剂,它的心血管电生理作用是:抑制心肌收缩力、张力最大变化速率和自律性,延长功能性不应期;具有负性肌力作用及负性频率作用,而对兴奋性无影响.粉防己碱直接阻滞心肌和血管平滑肌细胞的L型和T型钙电流,但并不移动钙电流的电流-电压曲线,以上作用对其治疗某些心血管疾病是非常有益的.此外粉防己碱还能分别抑制内皮细胞系及血管内皮细胞的 BK_(Ca)和 CRAC通道,此作用可能有助于改变血管内皮细胞的功能活动. Tetrandrine is a calcium channel blocker derived from plants. Its cardiovascular electrophysiological effects are: inhibition of myocardial contractility, maximum rate of change of tension and autonomy, prolong functional functional refractory period; have negative inotropic effect And negative frequency effect, but no effect on excitability. Tetrandrine directly blocks the L-type and T-type calcium currents of myocardial and vascular smooth muscle cells, but does not move the current-voltage curve of calcium currents. Some cardiovascular diseases are very beneficial. In addition, tetrandrine can also inhibit the BK_(Ca) and CRAC channels of endothelial cells and vascular endothelial cells, respectively. This effect may help to change the functional activities of vascular endothelial cells.