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过去认为使用单盐酸精氨酸静脉注射是安全的,因而用于治疗严重的代谢性碱中毒及测定垂体的功能。精氨酸和其他阳离子的氨基酸能使钾从细胞内转移到细胞外,并刺激钾的排泄。正常人使用精氨酸后只出现轻度的血钾升高,因为输入的精氨酸很快即被分解,过量的细胞外钾很快即被排泄。最近文献报告晚期肾功能衰竭进行透析患者使用精氨酸后引起严重的高血钾。作者报告两例严重肝脏疾患伴有中度肾功能不全患者,在使用单盐酸精氨酸静脉注射后引起严重高血钾病例。两例患者均因为严重的代谢性碱中毒,于分别使用60g和95g精氨酸后出现严重的高血钾,血钾分别为7.5mEq/L和7.1mEq/L。按高血钾症进行紧
In the past, intravenous administration of arginine monohydrochloride was considered safe and was therefore used to treat severe metabolic alkalosis and determine pituitary function. Arginine and other cationic amino acids can transfer potassium from the cell to the outside of the cell and stimulate potassium excretion. Normal use of arginine appears only mild hyperkalemia, because the input of arginine is quickly decomposed, excess extracellular potassium is quickly excreted. Recently reported in the literature late kidney failure for dialysis patients using arginine caused severe hyperkalemia. The authors report two cases of severe liver disease with moderate renal insufficiency in patients with arginine single hydrochloride intravenous injection caused serious cases of hyperkalemia. Both patients, with severe metabolic alkalosis, developed severe hyperkalemia with 60 and 95 g arginine, respectively, with serum potassium levels of 7.5 mEq / L and 7.1 mEq / L, respectively. Tight by hyperkalemia