宿主免疫系统对其固有菌丛处于相对不应答状态,对此虽有许多解释,但确切机制尚不清楚。这在免疫调节口腔菌丛方面很重要。在唾液及血清中均能测到自然产生的抗变链抗体,但其特异性,如何产生及如何控制细菌定居等方面都不清楚。本文作者以类似于人类感染的方式,研究了小鼠对变链Sobrinas定居的体液免疫应答。 Although the host immune system is in a relatively unresponsive state to its native flora, the exact mechanism is unclear, although there are many explanations. This is important in immunomodulating oral flora. Naturally occurring anti-chain variable antibodies can be detected in both saliva and serum, but its specificity, how it is produced and how to control bacterial colonization are unknown. In a manner similar to human infections, the authors studied the humoral immune response in mice to Sobrinas colonization.